Issue 12, 2014
From the journal:

Chemical Communications

Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement†

Peng He,a   Lijun Liu,a   Wenping Qiaoa  and  Shusheng Zhang*b  

* Corresponding authors

a Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China

b College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P.R. China
E-mail: shushzhang@126.com
Fax: +86-532-84022750
Tel: +86-532-84022750

Abstract

The surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) aptasensors combined with rolling circle amplification and bio-bar-coded AuNP enhancement have been applied to detect the human α-thrombin for the first time. The assay platform exhibited excellent selectivity and sensitivity with detection limit as low as 0.78 aM.

Graphical abstract: Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement

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Article information

DOI
https://doi.org/10.1039/C3CC48223E
Article type
Communication
Submitted
27 Oct 2013
Accepted
27 Nov 2013
First published
28 Nov 2013

Chem. Commun., 2014,50, 1481-1484

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Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement

P. He, L. Liu, W. Qiao and S. Zhang, Chem. Commun., 2014, 50, 1481 DOI: 10.1039/C3CC48223E

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