Issue 19, 2014

Ni(ii)–salt catalyzed activation of primary amine-sp3Cα–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles

Abstract

NiCl2·6H2O and Ni(OAc)2·4H2O were found as efficient catalysts for C–H activation of benzyl and aliphatic amines for an unprecedented multi C–N bond forming cyclization with 1,2-diketones under refluxing toluene to furnish highly substituted and polycyclic imidazoles.

Graphical abstract: Ni(ii)–salt catalyzed activation of primary amine-sp3Cα–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles

Supplementary files

Article information

Article type
Communication
Submitted
04 Nov 2013
Accepted
03 Dec 2013
First published
03 Dec 2013

Chem. Commun., 2014,50, 2477-2480

Author version available

Ni(II)–salt catalyzed activation of primary amine-sp3Cα–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles

S. Samanta, D. Roy, S. Khamarui and D. K. Maiti, Chem. Commun., 2014, 50, 2477 DOI: 10.1039/C3CC48437H

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