Issue 10, 2014

Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

Abstract

The solution phase synthesis of N-protected amino acids and peptides has been achieved through the Group-Assisted Purification (GAP) chemistry by avoiding disadvantages of other methods in regard to the difficult scale-up, expenses of solid and soluble polymers, etc. The GAP synthesis can reduce the use of solvents, silica gels, energy and manpower. In addition, the GAP auxiliary can be conveniently recovered for re-use and is environmentally friendly and benign, and substantially reduces waste production in academic labs and industry.

Graphical abstract: Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

Supplementary files

Article information

Article type
Communication
Submitted
07 Nov 2013
Accepted
26 Nov 2013
First published
27 Nov 2013

Chem. Commun., 2014,50, 1259-1261

Author version available

Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

J. Wu, G. An, S. Lin, J. Xie, W. Zhou, H. Sun, Y. Pan and G. Li, Chem. Commun., 2014, 50, 1259 DOI: 10.1039/C3CC48509A

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