Issue 15, 2014

Highly sensitive detection of telomerase using a telomere-triggered isothermal exponential amplification-based DNAzyme biosensor

Abstract

A telomere-triggered isothermal exponential amplification-based DNAzyme biosensor is developed for highly sensitive detection of telomerase in cancer cells even at the single-cell level. This biosensor can be further applied for the screening of telomerase inhibitors for anticancer drug development.

Graphical abstract: Highly sensitive detection of telomerase using a telomere-triggered isothermal exponential amplification-based DNAzyme biosensor

Supplementary files

Article information

Article type
Communication
Submitted
07 Nov 2013
Accepted
11 Dec 2013
First published
11 Dec 2013

Chem. Commun., 2014,50, 1909-1911

Highly sensitive detection of telomerase using a telomere-triggered isothermal exponential amplification-based DNAzyme biosensor

Y. Zhang, L. Wang and C. Zhang, Chem. Commun., 2014, 50, 1909 DOI: 10.1039/C3CC48518H

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