Issue 21, 2014

Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au–Ag nanoshells

Abstract

Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au–Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.

Graphical abstract: Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au–Ag nanoshells

Supplementary files

Article information

Article type
Communication
Submitted
12 Nov 2013
Accepted
14 Dec 2013
First published
16 Dec 2013

Chem. Commun., 2014,50, 2711-2714

Author version available

Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au–Ag nanoshells

Y. Wang, M. Salehi, M. Schütz and S. Schlücker, Chem. Commun., 2014, 50, 2711 DOI: 10.1039/C3CC48633H

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