Issue 32, 2014
From the journal:

Chemical Communications

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(ii) probe for in vivo imaging of live neurons†

Yu-Man Ho,‡a   Ngan-Pan Bennett Au,‡ab   Ka-Leung Wong,c   Chris Tsz-Leung Chan,d   Wai-Ming Kwok,d   Ga-Lai Law,d   Kwong-Kit Tang,e   Wai-Yeung Wong,c   Chi-Him Eddie Ma*abf  and  Michael Hon-Wah Lam*a  

* Corresponding authors

a Department of Biology & Chemistry, City University of Hong Kong, Tat Chee Ave., Kowloon, Hong Kong
E-mail: eddiema@cityu.edu.hk, bhmhwlam@cityu.edu.hk

b Centre for Biosystems, Neuroscience, and Nanotechnology, City University of Hong Kong, Tat Chee Avenue, Hong Kong

c Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Kowloon, Hong Kong

d Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong

e LSD – HK Division, Leica Microsystems Ltd, Hong Kong

f State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong Kong

Abstract

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}2+ (1) and {[Pt(L2)]2(μ-dppm)}2+ (2), as lysosome-specific two-photon imaging probes.

Graphical abstract: A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(ii) probe for in vivo imaging of live neurons

About
Cited by
Related
Download options Please wait...

Supplementary files

Additions and corrections

Article information

DOI
https://doi.org/10.1039/C3CC48934E
Article type
Communication
Submitted
22 Nov 2013
Accepted
24 Dec 2013
First published
03 Jan 2014

Chem. Commun., 2014,50, 4161-4163

Permissions

Request permissions

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Y. Ho, N. B. Au, K. Wong, C. T. Chan, W. Kwok, G. Law, K. Tang, W. Wong, C. E. Ma and M. H. Lam, Chem. Commun., 2014, 50, 4161 DOI: 10.1039/C3CC48934E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements