Issue 21, 2014
From the journal:

Chemical Communications

Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant†

Yun-He Xu,*a   Tao He,‡a   Qiu-Chi Zhang‡a  and  Teck-Peng Loh*ab  

* Corresponding authors

a Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China
E-mail: teckpeng@ntu.edu.sg
Fax: +65 6515 8229
Tel: +65 6513 8475

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616

Abstract

A cyclization reaction between enamides and alkynes catalyzed by palladium(II) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.

Graphical abstract: Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC49683J
Article type
Communication
Submitted
21 Dec 2013
Accepted
23 Jan 2014
First published
23 Jan 2014

Chem. Commun., 2014,50, 2784-2786

Author version available

Download author version (PDF)

Permissions

Request permissions

Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant

Y. Xu, T. He, Q. Zhang and T. Loh, Chem. Commun., 2014, 50, 2784 DOI: 10.1039/C3CC49683J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements