Issue 23, 2014
From the journal:

CrystEngComm

Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation†

Jose V. Parambil,ab   Sendhil K. Poornachary,c   Reginald B. H. Tanbc  and  Jerry Y. Y. Heng*a  

* Corresponding authors

a Surfaces and Particle Engineering Laboratory, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
E-mail: jerry.heng@imperial.ac.uk
Tel: +44 (0)20 7594 0784

b Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585

c Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore 627833

Abstract

Cooling crystallisation of carbamazepine solution in glass vials functionalised with different silane molecules resulted in preferential nucleation of metastable form II or stable form III polymorphs within a definite range of supersaturation. In contrast, the two crystal forms nucleated concomitantly on a control substrate under similar solution conditions.

Graphical abstract: Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation

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Article information

DOI
https://doi.org/10.1039/C3CE42622J
Article type
Communication
Submitted
24 Dec 2013
Accepted
04 Mar 2014
First published
04 Mar 2014

CrystEngComm, 2014,16, 4927-4930

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Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation

J. V. Parambil, S. K. Poornachary, R. B. H. Tan and J. Y. Y. Heng, CrystEngComm, 2014, 16, 4927 DOI: 10.1039/C3CE42622J

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