Issue 13, 2014
From the journal:

Physical Chemistry Chemical Physics

An intriguing pH-triggered FRET-based biosensor emission of a pyrazoline–doxorubicin couple and its application in living cells†

Dipak Kumar Rana,ab   Sayaree Dhara  and  Subhash Chandra Bhattacharya*a  

* Corresponding authors

a Department of Chemistry, Jadavpur University, Kolkata – 700032, India
E-mail: sbjuchem@yahoo.com, scbhattacharyya@chemistry.jdvu.ac.in
Fax: +91 (033)-2414 6584
Tel: +91 (033)-2414 6223

b Department of Chemistry, Saldiha College, Bankura – 722173, India

Abstract

A unique pH-driven Förster resonance energy transfer (FRET) based biosensor emission by a pyrazoline–doxorubicin pair has been deciphered with a bioimaging application in a live HepG2 cell whereas conformational switching of both molecules at elevated pH reveals a fascinating twist (FRET-OFF) via strong fluorescent exciplex formation.

Graphical abstract: An intriguing pH-triggered FRET-based biosensor emission of a pyrazoline–doxorubicin couple and its application in living cells

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Article information

DOI
https://doi.org/10.1039/C3CP54527J
Article type
Communication
Submitted
26 Oct 2013
Accepted
24 Dec 2013
First published
06 Jan 2014

Phys. Chem. Chem. Phys., 2014,16, 5933-5936

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An intriguing pH-triggered FRET-based biosensor emission of a pyrazoline–doxorubicin couple and its application in living cells

D. K. Rana, S. Dhar and S. C. Bhattacharya, Phys. Chem. Chem. Phys., 2014, 16, 5933 DOI: 10.1039/C3CP54527J

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