Issue 14, 2013

Recent progress in luminescent and colorimetric chemosensors for detection of thiols

Abstract

In the past few decades, the development of optical probes for thiols has attracted great attention because of the biological importance of the thiol-containing molecules such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH). This tutorial review focuses on various thiol detection methods based on luminescent or colorimetric spectrophotometry published during the period 2010–2012. The discussion covers a diversity of sensing mechanisms such as Michael addition, cyclization with aldehydes, conjugate addition–cyclization, cleavage of sulfonamide and sulfonate esters, thiolhalogen nucleophilic substitution, disulfide exchange, native chemical ligation (NCL), metal complex-displace coordination, and nanomaterial-related and DNA-based chemosensors.

Graphical abstract: Recent progress in luminescent and colorimetric chemosensors for detection of thiols

Article information

Article type
Tutorial Review
Submitted
25 Jan 2013
First published
20 May 2013

Chem. Soc. Rev., 2013,42, 6019-6031

Recent progress in luminescent and colorimetric chemosensors for detection of thiols

H. S. Jung, X. Chen, J. S. Kim and J. Yoon, Chem. Soc. Rev., 2013, 42, 6019 DOI: 10.1039/C3CS60024F

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