Issue 14, 2013
From the journal:

Chemical Society Reviews

Thiol-addition reactions and their applications in thiol recognition

Caixia Yin,†a   Fangjun Huo,†*b   Jingjing Zhang,a   Ramón Martínez-Máñez,*cd   Yutao Yang,ab   Haigang Lva  and  Sidian Li*a  

* Corresponding authors

a Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
E-mail: lisidian@sxu.edu.cn

b Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China
E-mail: huofj@sxu.edu.cn

c Centro Interuniversitario de Reconocimiento Molecular y Desarrollo Tecnológico, (IDM), Unidad Mixta Universidad Politécnica de Valencia – Universitat de València, Spain
E-mail: rmaez@qim.upv.es

d CIBER de Bioingeniería, Biomateriales y Nanotecnología (CIBER-BNN), Spain

Abstract

Because of the biological importance of thiols, the development of probes for thiols has been an active research area in recent years. In this review, we summarize the results of recent exciting reports regarding thiol-addition reactions and their applications in thiol recognition. The examples reported can be classified into four reaction types including 1,1, 1,2, 1,3, 1,4 addition reactions, according to their addition mechanisms, based on different Michael acceptors. In all cases, the reactions are coupled to color and/or emission changes, although some examples dealing with electrochemical recognition have also been included. The use of thiol-addition reactions is a very simple and straightforward procedure for the preparation of thiol-sensing probes.

Graphical abstract: Thiol-addition reactions and their applications in thiol recognition

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Article information

DOI
https://doi.org/10.1039/C3CS60055F
Article type
Review Article
Submitted
07 Feb 2013
First published
23 May 2013

Chem. Soc. Rev., 2013,42, 6032-6059

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Thiol-addition reactions and their applications in thiol recognition

C. Yin, F. Huo, J. Zhang, R. Martínez-Máñez, Y. Yang, H. Lv and S. Li, Chem. Soc. Rev., 2013, 42, 6032 DOI: 10.1039/C3CS60055F

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