Magnetic nanoparticle-supported guanidine as a highly recyclable and efficient nanocatalyst for the cyanosilylation of carbonyl compounds

Abstract

Guanidine supported onto magnetic Fe₃O₄ nanoparticles was prepared and evaluated as a recoverable interphase nanocatalyst for the cyanosilylation of carbonyl compounds in good to high yields using trimethylsilylcyanide (TMSCN) in CH₂Cl₂ at room temperature. This simple experimental and product isolation procedure combined with easy recovery and high reusability (up to 20) of the catalyst are expected to contribute to the development of clean strategy for the preparation of silylated cyanohydrins.