Issue 37, 2013
From the journal:

Dalton Transactions

Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand†

Cecilia Martín Santos,a   Silvia Cabrera,*a   Carla Ríos-Luci,b   José M. Padrón,b   Isabel López Solera,c   Adoración G. Quiroga,a   María A. Medrano,a   Carmen Navarro-Ranningera  and  José Alemán*d  

* Corresponding authors

a Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain
E-mail: silvia.cabrera@uam.es

b Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain

c Departamento de Química Inorgánica, Orgánica y Bioquímica, Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla La Mancha, Avda. Camilo José Cela 10, 13071 Ciudad Real, Spain

d Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain
E-mail: Jose.aleman@uam.es

Abstract

In this communication, we present the synthesis of new platinum complexes based on hydroxyquinoline ligands. We demonstrate the importance and the role of the halogen substitution as well as the chelation, which are essential structural characteristics for finding good cytotoxicities.

Graphical abstract: Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand

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Article information

DOI
https://doi.org/10.1039/C3DT51720A
Article type
Communication
Submitted
27 Jun 2013
Accepted
29 Jul 2013
First published
30 Jul 2013

Dalton Trans., 2013,42, 13343-13348

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Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand

C. Martín Santos, S. Cabrera, C. Ríos-Luci, J. M. Padrón, I. López Solera, A. G. Quiroga, M. A. Medrano, C. Navarro-Ranninger and J. Alemán, Dalton Trans., 2013, 42, 13343 DOI: 10.1039/C3DT51720A

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