Issue 14, 2014

Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

Abstract

A new turn-on cell permeable chemodosimetric probe 1 has been developed and its application in the selective detection of trivalent cations (Fe3+/Cr3+/Al3+) at a sub-nanomolar level has been demonstrated. The selectivity of 1 over a broad spectrum of mono- and divalent metal ions was established using fluorescence spectroscopy. Moreover, the changes in the absorption spectra of 1 in the presence of trivalent cations enabled the most bio-relevant metal ion Fe3+ over Cr3+/Al3+ to be distinguished. The probe was found to be successful in the fluorescence imaging of native cellular iron pools. The fluorescence imaging of the native iron pools of banana pith further supported the high sensitivity of 1 towards Fe3+ present in living systems. To the best of our knowledge, this is the first example of a turn-on chemodosimetric probe to image native cellular Fe3+ pools.

Graphical abstract: Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

Supplementary files

Article information

Article type
Communication
Submitted
06 Nov 2013
Accepted
19 Dec 2013
First published
24 Dec 2013

Dalton Trans., 2014,43, 5269-5273

Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

M. Venkateswarulu, T. Mukherjee, S. Mukherjee and R. R. Koner, Dalton Trans., 2014, 43, 5269 DOI: 10.1039/C3DT53141D

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