Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats†
Abstract
A key role of the
Maintenance work is planned for Wednesday 1st May 2024 from 9:00am to 11:00am (BST).
During this time, the performance of our website may be affected - searches may run slowly and some pages may be temporarily unavailable. If this happens, please try refreshing your web browser or try waiting two to three minutes before trying again.
We apologise for any inconvenience this might cause and thank you for your patience.
* Corresponding authors
a Manchester Centre for Integrative Systems Biology and Doctoral Training Centre ISBML, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, UK
b Drug Metabolism and Pharmacokinetics IM, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK
c
Oncology iMED DMPK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK
E-mail:
james.yates@astrazeneca.com
d Global Safety Assessment, Innovative Medicines, AstraZeneca R&D, Alderley Park, Macclesfield, UK
e Chair of Mathematical Modeling for Systems Toxicology, Université de Technologie de Compiègne, Royallieu Research Center, 60200 Compiegne, France
f INERIS, 60550 Verneuil-en-Halatte, France
g Dept of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College, Exhibition Rd, South Kensington, London, UK
h Molecular Cell Physiology, VU University, Amsterdam, The Netherlands
i Systems and Synthetic Biology, FNWI, Universiteit van Amsterdam, The Netherlands
A key role of the
Fetching data from CrossRef.
This may take some time to load.
Loading related content