Issue 6, 2014

Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release

Abstract

A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi–lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.

Graphical abstract: Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release

Supplementary files

Article information

Article type
Communication
Submitted
11 Nov 2013
Accepted
06 Jan 2014
First published
06 Jan 2014
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2014,14, 1083-1086

Author version available

Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release

B. Herranz-Blanco, L. R. Arriaga, E. Mäkilä, A. Correia, N. Shrestha, S. Mirza, D. A. Weitz, J. Salonen, J. Hirvonen and H. A. Santos, Lab Chip, 2014, 14, 1083 DOI: 10.1039/C3LC51260F

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