Issue 10, 2013
From the journal:

Molecular BioSystems

Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors†

Chung-Min Park,a   Yu Zhao,a   Zhaohui Zhu,b   Armando Pacheco,a   Bo Peng,a   Nelmi O. Devarie-Baez,a   Powell Bagdon,a   Hui Zhangb  and  Ming Xian*a  

* Corresponding authors

a Department of Chemistry, Washington State University, Pullman, WA 99164, USA
E-mail: mxian@wsu.edu
Fax: +1-509-335-8867
Tel: +1-509-335-6073

b Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164, USA

Abstract

A series of O-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mouse melanoma cells.

Graphical abstract: Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors

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Article information

DOI
https://doi.org/10.1039/C3MB70145J
Article type
Communication
Submitted
08 Apr 2013
Accepted
05 Jul 2013
First published
05 Jul 2013

Mol. BioSyst., 2013,9, 2430-2434

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Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors

C. Park, Y. Zhao, Z. Zhu, A. Pacheco, B. Peng, N. O. Devarie-Baez, P. Bagdon, H. Zhang and M. Xian, Mol. BioSyst., 2013, 9, 2430 DOI: 10.1039/C3MB70145J

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