Issue 5, 2013
From the journal:

MedChemComm

Synthesis and trypanocidal action of new adamantane substituted imidazolines†

Ana Koperniku,a   Ioannis Papanastasiou,a   George B. Foscolos,*a   Andrew Tsotinis,a   Martin C. Taylorb  and  John M. Kellyb  

* Corresponding authors

a Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece
E-mail: gfosc@pharm.uoa.gr
Fax: +30 210 7274747
Tel: +30 210 7274527

b Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
E-mail: john.kelly@lshtm.ac.uk
Fax: +44 (0)207 6368739
Tel: +44 (0)207 9272330

Abstract

Introduction of the hydrophobic substituents cyclopentyl, cyclohexyl and phenyl into adamantane imidazolines was accomplished with the synthesis of compounds 4. Members of this series were found to display a range of activities against bloodstream forms of Trypanosoma brucei.

Graphical abstract: Synthesis and trypanocidal action of new adamantane substituted imidazolines

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Article information

DOI
https://doi.org/10.1039/C3MD00081H
Article type
Concise Article
Submitted
13 Mar 2013
Accepted
31 Mar 2013
First published
02 Apr 2013

Med. Chem. Commun., 2013,4, 856-859

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Synthesis and trypanocidal action of new adamantane substituted imidazolines

A. Koperniku, I. Papanastasiou, G. B. Foscolos, A. Tsotinis, M. C. Taylor and J. M. Kelly, Med. Chem. Commun., 2013, 4, 856 DOI: 10.1039/C3MD00081H

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