Issue 3, 2013
From the journal:

MedChemComm

Prodrugionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form†

O. Andreea Cojocaru,a   Katharina Bica,b   Gabriela Gurau,a   Asako Narita,a   Parker D. McCrary,a   Julia L. Shamshina,a   Patrick S. Barbera  and  Robin D. Rogers*a  

* Corresponding authors

a Center for Green Manufacturing and Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487, USA
E-mail: rdrogers@as.ua.edu

b Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060 Vienna, Austria

Abstract

Neutral, non- or not easily-ionizable active pharmaceutical ingredients can take advantage of the unique property sets of ionic liquids by functionalization with hydrolyzable, charged (or ionizable) groups in the preparation of ionic liquid prodrugs as demonstrated here with the synthesis, characterization, and hydrolysis of cationic acetaminophen prodrugs paired with the docusate anion.

Graphical abstract: Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

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Article information

DOI
https://doi.org/10.1039/C3MD20359J
Article type
Concise Article
Submitted
03 Dec 2012
Accepted
14 Jan 2013
First published
17 Jan 2013

Med. Chem. Commun., 2013,4, 559-563

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Prodrug ionic liquids: functionalizing neutral active pharmaceutical ingredients to take advantage of the ionic liquid form

O. A. Cojocaru, K. Bica, G. Gurau, A. Narita, P. D. McCrary, J. L. Shamshina, P. S. Barber and R. D. Rogers, Med. Chem. Commun., 2013, 4, 559 DOI: 10.1039/C3MD20359J

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