Ruthenium complexes as novel inhibitors of human islet amyloid polypeptide fibril formation

Lei He; Xuesong Wang; Cong Zhao; Hongfei Wang; Weihong Du

doi:10.1039/C3MT00146F

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Ruthenium complexes as novel inhibitors of human islet amyloid polypeptide fibril formation†

Lei He,^a Xuesong Wang,^a Cong Zhao,^a Hongfei Wang^b and Weihong Du*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Renmin University of China, Beijing, China
E-mail: whdu@chem.ruc.edu.cn
Tel: +86 10-62512660

^b Institute of Opto-Electronics and Institute of Molecular Science, Shanxi University, Taiyuan, Shanxi Province, China

Abstract

Human islet amyloid polypeptide (hIAPP) can be linked to the pathology of type II diabetes. In this study, aromatic ring-containing Ru complexes were found to effectively inhibit the fibril formation of hIAPP and promote the disaggregation of formed fibrils by remarkably changing the β-sheet components.