Issue 11, 2013

Dendrimers as macromolecular tools to tackle from colon to brain tumor types: a concise overview

Abstract

It is well documented that dendrimers were described as one of the most tunable nanomaterials both for therapeutic applications and diagnostics. This concise review surveys the different types of both non-targeted and targeted drug-encapsulated dendrimers and dendrimer–drug conjugates in oncology. In addition, progress in biocompatible dendritic architectures is discussed as it relates to the development of anti-cancer agents through in vitro and in vivo studies. In particular, we present relevant examples of these nanodevices to treat aggressive cancers such as colon and brain tumors. This review concludes with a brief survey of perspectives for clinical translation.

Graphical abstract: Dendrimers as macromolecular tools to tackle from colon to brain tumor types: a concise overview

Article information

Article type
Perspective
Submitted
21 Mar 2013
Accepted
15 May 2013
First published
22 May 2013

New J. Chem., 2013,37, 3337-3357

Dendrimers as macromolecular tools to tackle from colon to brain tumor types: a concise overview

S. Mignani and J. Majoral, New J. Chem., 2013, 37, 3337 DOI: 10.1039/C3NJ00300K

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