Issue 4, 2014

Strategic innovation in the total synthesis of complex natural products using gold catalysis

Abstract

Covering: 2008 to 2013

Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further enhanced by the employment of gold catalysis on a routine basis to accomplish the total synthesis of natural products. In particular, the superior π acidity of the cationic gold complex for the activation of alkynes and allenes towards nucleophilic addition has significantly enriched the toolkit of transformations available to the total synthesis community, and inspired a new era of creativity in terms of the strategic disconnection of target compounds during their retrosynthetic analysis. Instead of simply supplementing the many existing reviews of gold catalysis, this review has been organized from the perspective of synthetic target families, with particular emphasis on the use of gold-catalyzed transformations during the late stages of syntheses involving complicated substrates, and cascade reactions that significantly increase molecular complexity.

Graphical abstract: Strategic innovation in the total synthesis of complex natural products using gold catalysis

Article information

Article type
Review Article
Submitted
15 Aug 2013
First published
30 Jan 2014

Nat. Prod. Rep., 2014,31, 489-503

Author version available

Strategic innovation in the total synthesis of complex natural products using gold catalysis

Y. Zhang, T. Luo and Z. Yang, Nat. Prod. Rep., 2014, 31, 489 DOI: 10.1039/C3NP70075E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements