Issue 18, 2013
From the journal:

Nanoscale

Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes†

Yeonju Lee,a   Goo-Eun Jung,b   Sang Joon Cho,bc   Kurt E. Geckeler*def  and  Harald Fuchs*aeg  

* Corresponding authors

a Physikalisches Institut, Universität Münster, Wilhelm Klemm-Str. 10, 48149 Münster, Germany
E-mail: fuchsh@uni-muenster.de

b Park Systems Corp., KANC 4F, Iui-Dong, 906-10, Suwon 443-270, Republic of Korea

c Advanced Institute of Convergence Technology, Seoul National University, Suwon, Republic of Korea

d School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea
E-mail: keg@gist.ac.kr

e Department of Nanobio Materials and Electronics (WCU), Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea

f Department of Medical System Engineering, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea

g Center for NanoTechnology (CeNTech), Heisenbergstr. 11, 48149 Münster, Germany

Abstract

Halloysite nanotube (HNT)-based supramolecular complexes are synthesized and evaluated with respect to their cytotoxicity and effects on cellular structures. As HNTs are water-insoluble, DNA is applied for wrapping the surface of HNTs to enhance their water-dispersibility. To investigate the potential of DNA-wrapped HNTs (HD) as a promising drug delivery carrier, doxorubicin (DOX) is introduced as a model anticancer agent and loaded onto HD. The DOX-loaded, DNA-wrapped HNTs (HDD) show sustained DOX release over two weeks without initial burst of DOX indicating delayed DOX release inside cells. In addition, effects of DNA-wrapped HNTs (HD) or HDD on the cytoskeleton organization of A549 cells are studied by visualizing the distribution of F-actin filaments using confocal laser scanning microscopy, and cellular morphological changes are observed by scanning electron microscopy and scanning ion conductance microscopy.

Graphical abstract: Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

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Article information

DOI
https://doi.org/10.1039/C3NR02665E
Article type
Paper
Submitted
22 May 2013
Accepted
02 Jul 2013
First published
29 Jul 2013

Nanoscale, 2013,5, 8577-8585

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Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

Y. Lee, G. Jung, S. J. Cho, K. E. Geckeler and H. Fuchs, Nanoscale, 2013, 5, 8577 DOI: 10.1039/C3NR02665E

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