Issue 21, 2013

Point-of-care nucleic acid detection using nanotechnology

Abstract

Recent developments in nanotechnology have led to significant advancements in point-of-care (POC) nucleic acid detection. The ability to sense DNA and RNA in a portable format leads to important applications for a range of settings, from on-site detection in the field to bedside diagnostics, in both developing and developed countries. We review recent innovations in three key process components for nucleic acid detection: sample preparation, target amplification, and read-out modalities. We discuss how the advancements realized by nanotechnology are making POC nucleic acid detection increasingly applicable for decentralized and accessible testing, in particular for the developing world.

Graphical abstract: Point-of-care nucleic acid detection using nanotechnology

Article information

Article type
Feature Article
Submitted
01 Aug 2013
Accepted
19 Aug 2013
First published
27 Aug 2013

Nanoscale, 2013,5, 10141-10154

Point-of-care nucleic acid detection using nanotechnology

M. R. Hartman, R. C. H. Ruiz, S. Hamada, C. Xu, K. G. Yancey, Y. Yu, W. Han and D. Luo, Nanoscale, 2013, 5, 10141 DOI: 10.1039/C3NR04015A

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