Issue 3, 2014

One-step nucleotide-programmed growth of porous upconversion nanoparticles: application to cell labeling and drug delivery

Abstract

A simple and “green” strategy has been reported for the first time to fabricate upconversion nanoparticles (UCNPs) by utilizing nucleotides as bio-templates. The influence of the functionalities present on the nucleotide on the production of nanoparticles was investigated in detail. Through the effects of nucleotides, the obtained nanoparticles possessed a porous structure. The use of the as-prepared UCNPs for cell imaging, drug delivery and versatile therapy applications were demonstrated. In view of the bright up-conversion luminescence as well as the excellent biocompatibility, and the good colloidal stability of the as-prepared UCNPs, we envision that our synthesis protocol might advance both the fields of UCNPs and biomolecule-based nanotechnology for future studies.

Graphical abstract: One-step nucleotide-programmed growth of porous upconversion nanoparticles: application to cell labeling and drug delivery

Supplementary files

Article information

Article type
Paper
Submitted
12 Aug 2013
Accepted
29 Oct 2013
First published
01 Nov 2013

Nanoscale, 2014,6, 1445-1452

One-step nucleotide-programmed growth of porous upconversion nanoparticles: application to cell labeling and drug delivery

L. Zhou, Z. Li, Z. Liu, M. Yin, J. Ren and X. Qu, Nanoscale, 2014, 6, 1445 DOI: 10.1039/C3NR04255C

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