Issue 14, 2013

Synthesis of imidazo and benzimidazo[2,1-a]isoquinolines by rhodium-catalyzed intramolecular double C–H bond activation

Abstract

The rhodium-catalyzed intramolecular direct arylation of imidazole and benzimidazole derivatives via double C–H bond activation is described. This approach provides new access to a wide range of imidazo and benzimidazo[2,1-a]isoquinoline derivatives in moderate to high yields. This reaction provides an alternative method to the known Pd-catalyzed intramolecular oxidative cross-coupling reactions.

Graphical abstract: Synthesis of imidazo and benzimidazo[2,1-a]isoquinolines by rhodium-catalyzed intramolecular double C–H bond activation

Supplementary files

Article information

Article type
Communication
Submitted
10 Dec 2012
Accepted
18 Feb 2013
First published
28 Feb 2013
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2013,11, 2249-2253

Synthesis of imidazo and benzimidazo[2,1-a]isoquinolines by rhodium-catalyzed intramolecular double C–H bond activation

V. P. Reddy, T. Iwasaki and N. Kambe, Org. Biomol. Chem., 2013, 11, 2249 DOI: 10.1039/C3OB27396B

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