Issue 40, 2013

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

Abstract

Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.

Graphical abstract: ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

Supplementary files

Article information

Article type
Paper
Submitted
11 Mar 2013
Accepted
02 Jul 2013
First published
30 Jul 2013

Org. Biomol. Chem., 2013,11, 6929-6933

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

E. Park, J. Dong and J. Shin, Org. Biomol. Chem., 2013, 11, 6929 DOI: 10.1039/C3OB40495A

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