Issue 25, 2013
From the journal:

Organic & Biomolecular Chemistry

A squaraine-based red emission off–on chemosensor for biothiols and its application in living cells imaging†

Xiao-Dong Liu,a   Ru Sun,a   Jian-Feng Ge,*a   Yu-Jie Xu,*b   Ying Xub  and  Jian-Mei Lu*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou 215123, China
E-mail: ge_jianfeng@hotmail.com, lujm@suda.edu.cn

b School of Radiation Medicine and Protection, Medicine College of Soochow University, Suzhou 215123, China
E-mail: dbnm@suda.edu.cn

Abstract

A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrile–PBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity and high sensitivity make it a potential probe with real applications. Moreover, the in vitro assays show that the probe can be used in fluorescence imaging for the detection of intracellular biothiol levels.

Graphical abstract: A squaraine-based red emission off–on chemosensor for biothiols and its application in living cells imaging

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Article information

DOI
https://doi.org/10.1039/C3OB40502H
Article type
Paper
Submitted
12 Mar 2013
Accepted
18 Apr 2013
First published
19 Apr 2013

Org. Biomol. Chem., 2013,11, 4258-4264

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A squaraine-based red emission off–on chemosensor for biothiols and its application in living cells imaging

X. Liu, R. Sun, J. Ge, Y. Xu, Y. Xu and J. Lu, Org. Biomol. Chem., 2013, 11, 4258 DOI: 10.1039/C3OB40502H

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