Issue 44, 2013
From the journal:

Organic & Biomolecular Chemistry

Copper catalyzed synthesis of fused benzimidazolopyrazine derivatives via tandem benzimidazole formation/annulation of δ-alkynyl aldehyde†

Subburethinam Ramesh,a   Suman Kr Ghosha  and  Rajagopal Nagarajan*a  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Hyderabad 500046, India
E-mail: rnsc@uohyd.ernet.in
Fax: +91-40-23012460
Tel: +91-40-23134831

Abstract

A novel route to synthesize the biologically active benzimidazolopyrazine core is outlined. The reaction proceeds via tandem benzimidazole formation/annulations of indole, pyrrole and aliphatic δ-alkynyl aldehydes in the presence of copper salts and green solvents with moderate to good yields.

Graphical abstract: Copper catalyzed synthesis of fused benzimidazolopyrazine derivatives via tandem benzimidazole formation/annulation of δ-alkynyl aldehyde

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Article information

DOI
https://doi.org/10.1039/C3OB41044G
Article type
Paper
Submitted
20 May 2013
Accepted
08 Aug 2013
First published
14 Aug 2013

Org. Biomol. Chem., 2013,11, 7712-7720

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Copper catalyzed synthesis of fused benzimidazolopyrazine derivatives via tandem benzimidazole formation/annulation of δ-alkynyl aldehyde

S. Ramesh, S. Kr Ghosh and R. Nagarajan, Org. Biomol. Chem., 2013, 11, 7712 DOI: 10.1039/C3OB41044G

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