Issue 36, 2013

Palladium-catalyzed carbenoid based N–H bond insertions: application to the synthesis of chiral α-amino esters

Abstract

A highly efficient palladium-catalyzed carbenoid based N–H bond insertion has been developed. The α-amino esters were obtained in high isolated yields. Moreover, by choosing a suitable chiral auxiliary, stereoselective Pd-catalyzed N–H insertion has been realized. The chiral α-amino esters were obtained in high yields (up to 91%) and with excellent diastereoselectivities (d.r. > 19 : 1).

Graphical abstract: Palladium-catalyzed carbenoid based N–H bond insertions: application to the synthesis of chiral α-amino esters

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2013
Accepted
22 Jul 2013
First published
23 Jul 2013

Org. Biomol. Chem., 2013,11, 5998-6002

Palladium-catalyzed carbenoid based N–H bond insertions: application to the synthesis of chiral α-amino esters

G. Liu, J. Li, L. Qiu, L. Liu, G. Xu, B. Ma and J. Sun, Org. Biomol. Chem., 2013, 11, 5998 DOI: 10.1039/C3OB41331D

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