Issue 42, 2013

Synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones via Pd-catalyzed cross-coupling reaction and cyclization

Abstract

Biologically active 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones have been synthesized in an efficient and concise manner utilizing readily available 4-hydroxyquinolin-2(1H)-ones as the starting material. The key strategy relies on the construction of the pyrrole ring through the palladium catalyzed sequential cross-coupling reaction and cyclization process.

Graphical abstract: Synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones via Pd-catalyzed cross-coupling reaction and cyclization

Supplementary files

Additions and corrections

Article information

Article type
Paper
Submitted
10 Aug 2013
Accepted
02 Sep 2013
First published
03 Sep 2013

Org. Biomol. Chem., 2013,11, 7334-7341

Synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones via Pd-catalyzed cross-coupling reaction and cyclization

Z. Wang, X. Xing, L. Xue, F. Gao and L. Fang, Org. Biomol. Chem., 2013, 11, 7334 DOI: 10.1039/C3OB41629A

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