A highly enantioselective method for the catalytic cis-stilbene oxide opening reaction with indole derivatives was developed. The scope of the reaction was studied with a selection of aromatic meso-epoxides and various indoles, and the desired 2-(indol-3-yl)ethanol derivatives were obtained in good to excellent yields with excellent enantioselectivities (from 96 to >99% ee).
B. Plancq, M. Lafantaisie, S. Companys, C. Maroun and T. Ollevier, Org. Biomol. Chem., 2013, 11, 7463 DOI: 10.1039/C3OB41782D
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