Issue 8, 2014

Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages

Abstract

RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did not interfere with normal base-pairing and A-type RNA conformation. Three consecutive amides were well tolerated in the passenger strand of siRNA and caused little change in RNAi activity.

Graphical abstract: Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages

Supplementary files

Article information

Article type
Communication
Submitted
18 Dec 2013
Accepted
06 Jan 2014
First published
07 Jan 2014

Org. Biomol. Chem., 2014,12, 1207-1210

Author version available

Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages

P. Tanui, S. D. Kennedy, B. D. Lunstad, A. Haas, D. Leake and E. Rozners, Org. Biomol. Chem., 2014, 12, 1207 DOI: 10.1039/C3OB42532K

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