Issue 9, 2013

RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity

Abstract

We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This phototrigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photocleavage, in a clean and very fast (a few nanoseconds) photoreaction. With an absorptivity coefficient εMAX = 5300 M−1 cm−1 at 447 nm and a quantum efficiency ϕ ∼ 0.09, RuBiGABA-2 is among the most active caged-GABAs, especially at long wavelengths. This highly hydrophilic caged GABA can be synthesized in a simple one-pot reaction. The synthesis, chemical characterization and photochemical properties are presented. Finally, the usefulness of this caged compound is demonstrated by photodelivering free GABA on leech motoneurons.

Graphical abstract: RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity

Supplementary files

Article information

Article type
Paper
Submitted
09 Jul 2012
Accepted
12 Apr 2013
First published
12 Apr 2013

Photochem. Photobiol. Sci., 2013,12, 1565-1570

RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity

O. Filevich and R. Etchenique, Photochem. Photobiol. Sci., 2013, 12, 1565 DOI: 10.1039/C3PP25248E

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