Issue 2, 2014

Polymerization-Induced Self-Assembly (PISA) – control over the morphology of nanoparticles for drug delivery applications

Abstract

In this paper, we describe the synthesis of asymmetric functional POEGMA-b-P(ST-co-VBA) copolymers in methanol, yielding in one-pot polymerization a range of nanoparticle morphologies, including spherical micelles, worm-like, rod-like micelles and vesicles. The presence of the aldehyde group was then exploited to form crosslinks or to conjugate chemotherapy compounds, such as doxorubicin, via pH-breakable bonds (Schiff base or imine) directly to the preformed nanoparticles. The influence of the nanoparticle morphologies on the MCF-7 breast cancer cell line uptake was investigated using flow cytometry and confocal microscopy. Finally, the IC50 of DOX, following nanoparticle delivery, was studied showing significant influence of the nanoparticle carrier morphology on therapeutic efficacy for breast cancer.

Graphical abstract: Polymerization-Induced Self-Assembly (PISA) – control over the morphology of nanoparticles for drug delivery applications

Supplementary files

Article information

Article type
Communication
Submitted
19 Sep 2013
Accepted
01 Oct 2013
First published
22 Oct 2013

Polym. Chem., 2014,5, 350-355

Polymerization-Induced Self-Assembly (PISA) – control over the morphology of nanoparticles for drug delivery applications

B. Karagoz, L. Esser, H. T. Duong, J. S. Basuki, C. Boyer and T. P. Davis, Polym. Chem., 2014, 5, 350 DOI: 10.1039/C3PY01306E

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