Issue 21, 2013
From the journal:

RSC Advances

Dichrocephones A and B, two cytotoxic sesquiterpenoids with the unique [3.3.3] propellane nucleus skeleton from Dichrocephala benthamii†

Xinhui Tian,a   Li Li,b   Yanbao Hu,a   Hongwu Zhang,a   Yuetao Liu,a   Hong Chen,c   Gang Ding*a  and  Zhongmei Zou*a  

* Corresponding authors

a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
E-mail: zmzou@implad.ac.cn, gding@implad.ac.cn

b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China

c Medical College of Chinese People's Armed Police Force, Tianjin, P. R. China

Abstract

Dichrocephones A (1) and B (2), two new modhephane sesquiterpenoids containing the key core skeleton as that of modhephane sesquiterpenoids rarely encountered in nature were isolated from Dichrocephala benthamii. Dichrocephone B (2) contains a new ring system formed by the [3.3.3] propellane core structure fused to a unique oxetane ring with significant cytotoxicity against HeLa, KB and A549 cell lines.

Graphical abstract: Dichrocephones A and B, two cytotoxic sesquiterpenoids with the unique [3.3.3] propellane nucleus skeleton from Dichrocephala benthamii

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Article information

DOI
https://doi.org/10.1039/C3RA23364B
Article type
Paper
Submitted
17 Dec 2012
Accepted
06 Mar 2013
First published
06 Mar 2013

RSC Adv., 2013,3, 7880-7883

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Dichrocephones A and B, two cytotoxic sesquiterpenoids with the unique [3.3.3] propellane nucleus skeleton from Dichrocephala benthamii

X. Tian, L. Li, Y. Hu, H. Zhang, Y. Liu, H. Chen, G. Ding and Z. Zou, RSC Adv., 2013, 3, 7880 DOI: 10.1039/C3RA23364B

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