Issue 19, 2013
From the journal:

RSC Advances

Click reaction-mediated functionalization of near-infrared pyrrolopyrrole cyanine dyes for biological imaging applications†

Mingzhou Zhou,a   Xuan Zhang,a   Mingfeng Bai,a   Duanwen Shen,a   Baogang Xu,a   Jeffery Kao,b   Xia Geb  and  Samuel Achilefu*a  

* Corresponding authors

a Department of Radiology, Optical Radiology Laboratory, Washington University School of Medicine, 4525 Scott Avenue, Saint Louis, MO 63108, USA
E-mail: achilefus@mir.wustl.edu
Fax: 314-747-5191
Tel: 314-362-8599

b Departments of Chemistry, Washington University, 1 Brookings Drive, St. Louis, Missouri 63130, USA

Abstract

Clickable pyrrolopyrrole cyanine (PPCy) dyes were synthesized by incorporating an alkyne moiety, followed by click reaction with azide-functionalized molecules of different polarities. The clickable dyes are readily amenable to labelling diverse molecules and exhibit exceptionally high photostabilities and impressive fluorescence quantum yields.

Graphical abstract: Click reaction-mediated functionalization of near-infrared pyrrolopyrrole cyanine dyes for biological imaging applications

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Article information

DOI
https://doi.org/10.1039/C3RA40441B
Article type
Communication
Submitted
25 Jan 2013
Accepted
15 Mar 2013
First published
15 Mar 2013

RSC Adv., 2013,3, 6756-6758

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Click reaction-mediated functionalization of near-infrared pyrrolopyrrole cyanine dyes for biological imaging applications

M. Zhou, X. Zhang, M. Bai, D. Shen, B. Xu, J. Kao, X. Ge and S. Achilefu, RSC Adv., 2013, 3, 6756 DOI: 10.1039/C3RA40441B

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