Three-component synthesis of a polysubstituted pyrrole core containing heterocyclic scaffolds over magnetically separable nanocrystalline copper ferrite

Abstract

A highly convergent, efficient and practical heteroannulation protocol for the synthesis of a library of coumarin and uracil fused pyrrole derivatives has been developed. Reactions involving the CuFe₂O₄ catalyzed one-pot three-component domino coupling of 6-aminouracil/4-aminocoumarin, aldehydes and nitromethane resulted in highly substituted coumarin and uracil fused pyrrole derivatives, making this strategy very useful in diversity-oriented synthesis (DOS). CuFe₂O₄ magnetic nanoparticles were prepared by a simple and effective citric acid complex method and characterized by using XRD, FT-IR, and TEM images. The easy recovery of the catalyst and high yield of the products makes the protocol attractive, sustainable and economic. The catalyst was recycled for six cycles with almost unaltered catalytic activity.