Issue 22, 2013
From the journal:

RSC Advances

Copper-catalyzed N-arylation and aerobic oxidative C–H/C–H coupling: one-pot synthesis of indoloimidazoquinoline derivatives†

Meng Wang,ab   Yunhe Jin,a   Haijun Yang,a   Hua Fu*ac  and  Liming Hu*b  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
E-mail: fuhua@mail.tsinghua.edu.cn

b College of Life Sciences and Bioengineering, Beijing University of Technology, Beijing 100124, P. R. China
E-mail: huliming@bjut.edu.cn

c Key Laboratory of Chemical Biology (Guangdong Province), Graduate School of Shenzhen, Tsinghua University, Shenzhen 518057, P. R. China

Abstract

A novel and efficient copper-catalyzed one-pot synthesis of indoloimidazoquinoline derivatives has been developed. The protocol uses the readily available substituted 2-(2-bromophenyl)-1H-indoles, imidazole and benzoimidazoles as the starting materials, inexpensive CuBr as the catalyst, air as the terminal oxidant, and the procedure underwent a sequential copper-catalyzed intermolecular N-arylation and an aerobic oxidative intramolecular C–H/C–H coupling.

Graphical abstract: Copper-catalyzed N-arylation and aerobic oxidative C–H/C–H coupling: one-pot synthesis of indoloimidazoquinoline derivatives

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Article information

DOI
https://doi.org/10.1039/C3RA40999F
Article type
Communication
Submitted
27 Feb 2013
Accepted
10 Apr 2013
First published
10 Apr 2013

RSC Adv., 2013,3, 8211-8214

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Copper-catalyzed N-arylation and aerobic oxidative C–H/C–H coupling: one-pot synthesis of indoloimidazoquinoline derivatives

M. Wang, Y. Jin, H. Yang, H. Fu and L. Hu, RSC Adv., 2013, 3, 8211 DOI: 10.1039/C3RA40999F

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