Issue 24, 2013
From the journal:

RSC Advances

A recyclable CuO-catalyzed synthesis of 4(3H)-quinazolinones†

Dan Zhan,a   Tianbin Li,a   Haidong Wei,a   Wen Weng,b   Khashayar Ghandic  and  Qingle Zeng*a  

* Corresponding authors

a Institute of Green Catalysis and Synthesis, State Key Lab of Geohazard Prevention and Geoenvironment Protection, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China
E-mail: qinglezeng@hotmail.com

b Department of Chemistry and Environmental Science, Zhangzhou Normal University, Zhangzhou 363000, PR China

c Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, Canada

Abstract

This paper describes the synthesis of 2-substituted and 2,3-disubstituted 4(3H)-quinazolinones via a tandem reaction involving anthranilamides and aromatic aldehydes catalyzed by 3 mol% CuO powder under air atmosphere. This new method has several advantages: it uses recyclable and cheap CuO powder as the catalyst and air as the green oxidant, water is the only byproduct, and the solvent is recycled. It is easy to run, has a high atom economy and good to excellent yields. A mechanism for the CuO-catalyzed synthesis of the 4(3H)-quinazolinones is proposed.

Graphical abstract: A recyclable CuO-catalyzed synthesis of 4(3H)-quinazolinones

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Article information

DOI
https://doi.org/10.1039/C3RA41370E
Article type
Paper
Submitted
13 Dec 2012
Accepted
28 Mar 2013
First published
03 Apr 2013

RSC Adv., 2013,3, 9325-9329

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A recyclable CuO-catalyzed synthesis of 4(3H)-quinazolinones

D. Zhan, T. Li, H. Wei, W. Weng, K. Ghandi and Q. Zeng, RSC Adv., 2013, 3, 9325 DOI: 10.1039/C3RA41370E

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