Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release†
Abstract
We report a “one-pot” method to synthesize an amphiphilic triblock copolymer with multiple pendant mercapto groups in the hydrophilic block. Shell crosslinked micelles were prepared in a facile manner via the self-assembly of this copolymer in aqueous solution and crosslinking of the micellar shell by H2O2. These shell crosslinked micelles show rapid bioreductive responsiveness for anticancer drug release.