Issue 40, 2013

Synthesis of indolizidine, pyrrolizidine and quinolizidine ring systems by proline-catalyzed sequential α-amination and HWE olefination of an aldehyde

Abstract

A general procedure for the synthesis of azabicyclic ring systems viz. indolizidine, pyrrolizidine and quinolizidine has been developed utilizing proline-catalyzed sequential α-amination and Horner–Wadsworth–Emmons (HWE) olefination of an aldehyde as the key step. This method can be further extended to the synthesis of various biologically active natural products containing azabicyclic ring systems.

Graphical abstract: Synthesis of indolizidine, pyrrolizidine and quinolizidine ring systems by proline-catalyzed sequential α-amination and HWE olefination of an aldehyde

Supplementary files

Article information

Article type
Communication
Submitted
23 Apr 2013
Accepted
02 Aug 2013
First published
02 Aug 2013

RSC Adv., 2013,3, 18288-18291

Synthesis of indolizidine, pyrrolizidine and quinolizidine ring systems by proline-catalyzed sequential α-amination and HWE olefination of an aldehyde

S. V. Kauloorkar, V. Jha and P. Kumar, RSC Adv., 2013, 3, 18288 DOI: 10.1039/C3RA42001A

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