Issue 40, 2013

Photobactericidal polymers; the incorporation of crystal violet and nanogold into medical grade silicone

Abstract

Crystal violet and 2 nm gold nanoparticles were incorporated into medical grade silicone polymers by use of a novel two-step dipping strategy using water and wateracetone mixtures. Optical microscopic examination showed that the optimised polymer incorporated dye close to the polymer surface, with minimal dye encapsulation throughout the polymer bulk. The modified polymer was stable under aqueous conditions with negligible leaching of crystal violet from the polymer into surrounding aqueous solution at 37 °C. Exposure of the modified silicone to low power 635 nm laser light induced the lethal photosensitisation of both Staphylococcus epidermidis and Escherichia coli. Despite the laser used not matching the absorption maximum of the crystal violet-containing silicone samples, the lethal photosensitisation was the highest reported, in terms of bacterial kill per energy dose. Furthermore, surprisingly, some statistically significant dark kill was also noted.

Graphical abstract: Photobactericidal polymers; the incorporation of crystal violet and nanogold into medical grade silicone

Article information

Article type
Paper
Submitted
12 Mar 2013
Accepted
25 Jun 2013
First published
08 Jul 2013

RSC Adv., 2013,3, 18383-18394

Photobactericidal polymers; the incorporation of crystal violet and nanogold into medical grade silicone

S. Noimark, M. Bovis, A. J. MacRobert, A. Correia, E. Allan, M. Wilson and I. P. Parkin, RSC Adv., 2013, 3, 18383 DOI: 10.1039/C3RA42629G

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