Issue 45, 2013
From the journal:

RSC Advances

Synthesis of unnatural indolizidines, pyrrolizidine and C-alkyl iminosugars from sugar derived hemiaminals†

Rima Lahiri,a   Y. Suman Reddy,a   Sudhir A. Kulkarnib  and  Yashwant D. Vankar*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology, Kanpur-208016, India
E-mail: vankar@iitk.ac.in

b VLife Sciences Technologies Pvt. Ltd., 2nd Floor Anaahat, Plot No. 5, Ram Indu Park, Baner Road, Pune 411045, India
E-mail: sudhirk@vlifesciences.com
Fax: +91-512-2597436

Abstract

Novel biologically important mono- and bicyclic iminosugars have been synthesized from commercially available sugars following high yielding and short synthetic sequences. These unnatural N-heterocycles have been further tested against several glycosidases and some of them showed good inhibition of the enzymes with moderate selectivity.

Graphical abstract: Synthesis of unnatural indolizidines, pyrrolizidine and C-alkyl iminosugars from sugar derived hemiaminals

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Article information

DOI
https://doi.org/10.1039/C3RA43510E
Article type
Paper
Submitted
10 Jul 2013
Accepted
23 Sep 2013
First published
25 Sep 2013

RSC Adv., 2013,3, 23242-23254

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Synthesis of unnatural indolizidines, pyrrolizidine and C-alkyl iminosugars from sugar derived hemiaminals

R. Lahiri, Y. Suman Reddy, S. A. Kulkarni and Y. D. Vankar, RSC Adv., 2013, 3, 23242 DOI: 10.1039/C3RA43510E

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