Molecular iodine: a green and inclusive catalyst for the synthesis of highly functionalized 1,3,5-trisubstituted pyrazoles in aqueous medium

Abstract

A library of 1,3,5-trisubstituted pyrazoles was synthesized in excellent yields from the reaction of aldehyde, phenylhydrazine and alkynes in the presence of iodine via an eco-friendly, simple process performed in aqueous medium. This single pot transformation generates new CN, C–C, C–N bonds and proceeds by a domino reaction involving the formation of Schiff base, Mannich addition and finally intramolecular cyclisation.