Issue 5, 2014
From the journal:

RSC Advances

Syntheses of indolo[1,2-a]quinazolinone derivatives via palladium catalyzed intramolecular C–H amidation†

Trimurtulu Kotipalli,a   Veerababurao Kavala,a   Donala Janreddy,a   Chun-Wei Kuo,a   Ting-Shen Kuo,a   Hsiu-Ni Huang,a   Chiu-Hui Hea  and  Ching-Fa Yao*a  

* Corresponding authors

a Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, Taiwan 116, Republic of China
E-mail: cheyaocf@ntnu.edu.tw

Abstract

The synthesis of indolo[1,2-a]quinazolinone starting from 2-iodobenzamide and indole derivatives is reported. In this two-step procedure, indole is N-arylated with 2-iodobenzamide derivatives via Ullman coupling, followed by an intramolecular C–H amidation using a palladium catalyst.

Graphical abstract: Syntheses of indolo[1,2-a]quinazolinone derivatives via palladium catalyzed intramolecular C–H amidation

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Article information

DOI
https://doi.org/10.1039/C3RA44798G
Article type
Paper
Submitted
03 Sep 2013
Accepted
18 Nov 2013
First published
21 Nov 2013

RSC Adv., 2014,4, 2274-2283

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Syntheses of indolo[1,2-a]quinazolinone derivatives via palladium catalyzed intramolecular C–H amidation

T. Kotipalli, V. Kavala, D. Janreddy, C. Kuo, T. Kuo, H. Huang, C. He and C. Yao, RSC Adv., 2014, 4, 2274 DOI: 10.1039/C3RA44798G

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