Issue 46, 2013

Antithrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics

Abstract

Controlling platelet activation and clotting initiated by cardiovascular interventions remains a major challenge in clinical practice. In this work, the antithrombotic properties of a polysaccharide-based nitric oxide (NO)-releasing dextran derivative are presented. Total platelet adhesion, platelet morphology and whole blood clotting kinetics were used as indicators to evaluate the anticlotting properties of this material. With a total NO delivery of 0.203 ± 0.003 μmol, the NO-releasing dextran derivative (Dex–SNO) mixed with blood plasma demonstrated a significantly lower amount of platelet adhesion and activation onto a surface and reduced whole blood clotting kinetics. Nearly 75% reduction in platelet adhesion and a significant retention of platelet morphology were observed with blood plasma treated with Dex–SNO, suggesting this to be a potential antiplatelet therapeutic agent for preventing thrombosis that does not have an adverse effect on circulating platelets.

Graphical abstract: Antithrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics

Article information

Article type
Paper
Submitted
02 Oct 2013
Accepted
10 Oct 2013
First published
10 Oct 2013

RSC Adv., 2013,3, 24406-24414

Antithrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics

V. B. Damodaran, V. Leszczak, K. A. Wold, S. M. Lantvit, K. C. Popat and M. M. Reynolds, RSC Adv., 2013, 3, 24406 DOI: 10.1039/C3RA45521A

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