Unprecedented catalytic activity of Mn3O4 nanoparticles: potential lead of a sustainable therapeutic agent for hyperbilirubinemia

Anupam Giri; Nirmal Goswami; Chandan Sasmal; Nabarun Polley; Dipanwita Majumdar; Sounik Sarkar; Sambhu Nath Bandyopadhyay; Achintya Singha; Samir Kumar Pal

doi:10.1039/C3RA45545A

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Unprecedented catalytic activity of Mn₃O₄ nanoparticles: potential lead of a sustainable therapeutic agent for hyperbilirubinemia†

Anupam Giri,^a Nirmal Goswami,^a Chandan Sasmal,^b Nabarun Polley,^a Dipanwita Majumdar,^c Sounik Sarkar,^d Sambhu Nath Bandyopadhyay,^b Achintya Singha^c and Samir Kumar Pal*^a

Author affiliations

* Corresponding authors

^a Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India
E-mail: skpal@bose.res.in

^b Department of Obstetrics & Gynaecology, Institute of Post Graduate Medical Education and Research (IPGME&R), 244 A. J. C Bose Road, Kolkata, India

^c Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata 700 009, India

^d Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, India

Abstract

We report an unprecedented catalytic decomposition of aqueous bilirubin solution, without any photo-activation, by citrate functionalized Mn₃O₄ nanoparticles (NPs). In vitro reactivity of the catalyst on the whole blood specimen of hyperbilirubinemia patients revealed that the catalyst can significantly suppress the total bilirubin level in the blood specimens.

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Article information

DOI: https://doi.org/10.1039/C3RA45545A
Article type: Communication
Submitted: 03 Oct 2013
Accepted: 10 Dec 2013
First published: 11 Dec 2013

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RSC Adv., 2014,4, 5075-5079

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Unprecedented catalytic activity of Mn₃O₄ nanoparticles: potential lead of a sustainable therapeutic agent for hyperbilirubinemia

A. Giri, N. Goswami, C. Sasmal, N. Polley, D. Majumdar, S. Sarkar, S. N. Bandyopadhyay, A. Singha and S. K. Pal, RSC Adv., 2014, 4, 5075 DOI: 10.1039/C3RA45545A

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