Issue 25, 2014

meta-Chloroperbenzoic acid (mCPBA): a versatile reagent in organic synthesis

Abstract

The synthetic uses of different peroxides for organic synthesis have been widely studied. Among these peroxides, meta-chloroperbenzoic acid (mCPBA) is an efficient oxidizing reagent and have been used for many oxidative transformations. mCPBA is widely used for chemical transformations such as the oxidation of carbonyl compounds, iminoindolines, olefins, imines, alkanes, silyl enol ethers, N- and S-heterocycles, active methylene groups, fluoromethylated allylic bromides, cyclic acetals, N-substituted phthalimidines, selenides, furans and phosphates. The purpose of this review is to collect and discuss the synthetic applications of meta-chloroperbenzoic acid (mCPBA) over the past few decades.

Graphical abstract: meta-Chloroperbenzoic acid (mCPBA): a versatile reagent in organic synthesis

Article information

Article type
Review Article
Submitted
14 Oct 2013
Accepted
16 Jan 2014
First published
17 Jan 2014

RSC Adv., 2014,4, 12882-12917

Author version available

meta-Chloroperbenzoic acid (mCPBA): a versatile reagent in organic synthesis

H. Hussain, A. Al-Harrasi, I. R. Green, I. Ahmed, G. Abbas and N. U. Rehman, RSC Adv., 2014, 4, 12882 DOI: 10.1039/C3RA45702H

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