High-efficiency loading in small mesopores (2–3 nm) forming a matrix type controlled drug delivery nanosystem

Fang Liu; Hongwu Zhang; Qingyun Cao; Xianhong Xiang; Liqin Wang; Ting He; Wei Liu; Yueping Fang; David Y. B. Deng; Wuyi Zhou

doi:10.1039/C3RA47035K

High-efficiency loading in small mesopores (2–3 nm) forming a matrix type controlled drug delivery nanosystem†

Fang Liu,‡^a Hongwu Zhang,‡^b Qingyun Cao,^c Xianhong Xiang,^d Liqin Wang,^d Ting He,^a Wei Liu,^a Yueping Fang,^a David Y. B. Deng*^b and Wuyi Zhou*^a

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* Corresponding authors

^a Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China
E-mail: zhouwuyi@scau.edu.cn
Fax: +86-20-85285026
Tel: +86-20-85280325

^b Research Center of Translational Medicine, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
E-mail: dengyub@mail.sysu.edu.cn
Fax: +86-20-37616451
Tel: +86-20-87755766-8630

^c College of Animal Science, South China Agricultural University, Guangzhou, China

^d Department of Interventional Radiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China

Abstract

Herein a high-efficiency controlled release nanosystem for fluoroquinolone hydrochlorides was established by a characteristic vacuum-recrystal loaded process based on small pore mesoporous MCM-41. The system exhibited great drug loading capacity (62.31%), matrix type sustained-release behavior (5 days) and excellent biocompatibility in vitro.

RSC Advances

High-efficiency loading in small mesopores (2–3 nm) forming a matrix type controlled drug delivery nanosystem†

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High-efficiency loading in small mesopores (2–3 nm) forming a matrix type controlled drug delivery nanosystem

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